For anyone is interested:
I removed the OpenDNS IP Address from within DNS / Forwarders and the network clients have not experienced any additional negative issues browsing the Internet (WAN).
In the Feature:
I would like to use OpenDNS, but before I do I will build a new route, apply all of the patches (including the OpenDNS patch) and then duplicate the existing network. But not at this time.
The Layor7 blocking rules are working great.
Thank you Fulvio Riccardi, and thank you ZS